MiR-34a Knockout Mouse Model Data for Alzheimer's Disease Research

A 16.9 KB Excel dataset from a study investigating the role of miR-34a in Alzheimer's disease pathogenesis. The data, authored by Junling Yang and last updated in March 2026, includes results from cognitive testing, neuropathological evaluation, and hippocampal transcriptomics in a transgenic mouse model. Findings suggest miR-34a deficiency enhances nucleic acid sensing and type I interferon signaling.

Use Cases

• Analyze gene expression changes related to type I interferon signaling based on bulk RNA-seq results mentioned in the description
• Correlate cognitive function outcomes with amyloid-beta peptide ratios based on Morris water maze and biochemical data
• Investigate microglial activation states and interferon-responsive microglia (IRM) gene signatures based on immunohistochemistry and transcriptomics

Strengths

• Data is associated with a published experimental study involving multiple methodologies (RNA-seq, immunohistochemistry, behavioral tests)
• Dataset is openly available under a CC-BY-4.0 license
• Last updated March 2026, indicating recent curation

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• Dataset is very small (16.9 KB), indicating limited scope or summary-level data

Provenance

Source

figshare, authored by Junling Yang

Collection Method

Experimental data from a mouse model study, likely containing processed results from RNA-seq, qPCR, and pathological analysis

Time Range

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Freshness

Last updated 2026-03-17 13:08:23

Geography

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