Data Sheet 3_Multi-layer transcriptomic analyses identify a mucin-associated epithelial pr

A 2026 study by Jianmin Huang integrates bulk, single-cell, and spatial transcriptomic analyses to investigate epithelial barrier disruption in ulcerative colitis. The research identifies a GALNT12-centered mucin-associated epithelial program linked to barrier resilience and inflammatory injury. The underlying data is shared via figshare under a CC-BY-4.0 license.

Use Cases

• Prioritizing candidate genes for ulcerative colitis based on multi-omic integration described in the study.
• Investigating mucin-type O-glycosylation gene dysregulation in epithelial cells using the identified 15-gene signature.
• Analyzing cell-cell communication networks between MUC2-positive epithelial cells and stromal/immune populations as inferred from the data.
• Validating GALNT12's role in epithelial barrier function and cytokine-induced injury using the described knockdown model.

Strengths

• Integrates three transcriptomic analysis layers: bulk, single-cell, and spatial.
• Identifies and functionally validates a specific candidate gene, GALNT12.
• Data is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 616.5 KB PDF, suggesting it contains summarized results rather than raw data files.
• Column-level documentation and sample data are unavailable, limiting direct computational reuse.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Integrated analysis of transcriptomic datasets (e.g., GSE107499) with functional validation in cell models.

Freshness

Last updated 2026-06-03 04:47:32.