RETRACTED: Experimental Data on 2-Methoxyestradiol Effects in Rat Subarachnoid Hemorrhage

A 20.2 KB document by Qiang Hu, last updated in April 2026, describes a retracted study on early brain injury in rats. The research investigates the effects of 2-Methoxyestradiol on neuroinflammation and brain edema 24 hours after induced subarachnoid hemorrhage. Methods included neurological scoring, brain water content measurement, and analysis of inflammatory factors and tight junction proteins.

Use Cases

• Analyzing the relationship between drug intervention and neurological scores based on described experimental outcomes.
• Studying biomarker expression (e.g., IL-1β, TNF-α, ZO-1) in a controlled animal model of brain injury.
• Investigating the correlation between microglial activation and blood-brain barrier permeability changes post-injury.
• Examining the mechanistic pathway involving HIF-1α, VEGF, and MMP-9 in neuroinflammation as described.

Strengths

• The description provides a detailed methodological account of the experimental protocol and measured outcomes.
• License is clearly defined as CC-BY-4.0, facilitating open reuse.
• Specific temporal marker (24 hours post-injury) is provided for the primary measurements.

Limitations

• The dataset is a retracted study document; its scientific validity is questionable.
• The actual data file is a 20.2 KB DOCX, suggesting it contains a manuscript or report, not raw structured data.
• Row count and column definitions are completely unknown, limiting assessment of data utility.

Provenance

Source

figshare, author Qiang Hu.

Collection Method

Experimental data from a rat endovascular puncture model of subarachnoid hemorrhage.

Time Range

Measurements taken at 24 hours post-injury.

Freshness

Last updated 2026-04-27 13:30:29; freshness should be verified.

Geography

Laboratory study; geographic location is unknown.