SBC8803: Zebrafish Gut-Brain Multi-Omics Data for Psychobiotic Research

Multi-omics data from a study investigating the anxiolytic effects of the paraprobiotic Lactobacillus brevis SBC8803 in adult zebrafish. The dataset includes behavioral metrics, brain transcriptomic profiles, and 16S rRNA amplicon sequencing of intestinal contents from fish fed the treatment for 4 weeks. Authored by Azusa Kubota and shared under a CC-BY-4.0 license on figshare in May 2026.

Use Cases

• Identify correlations between gut microbiome composition and brain gene expression based on integrated multi-omics analyses.
• Model anxiolytic behavioral outcomes based on serotonin receptor and oxytocin signaling pathway enrichment.
• Investigate microbial metabolic shifts in lipid and vitamin metabolism linked to behavioral changes.
• Explore innate gut-brain coordination independent of treatment effects using residual correlation analysis.

Strengths

• Integrates three data modalities: behavioral assays, brain RNA-seq, and 16S rRNA microbiome sequencing.
• Study design includes a 4-week controlled feeding trial with a specific paraprobiotic strain.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (2.4 MB), suggesting it may contain summary or processed results rather than raw sequencing reads.

Provenance

Source

figshare

Collection Method

Experimental study involving adult male AB-strain zebrafish fed a diet containing heat-killed Lactobacillus brevis SBC8803 for 4 weeks, followed by behavioral testing, RNA sequencing, and 16S rRNA amplicon sequencing.

Freshness

Last updated 2026-05-21 05:35:23; freshness should be verified.