Cow's Milk Allergy Multi-Omics Review with Single-Cell RNA-Seq Corroboration

39 studies of infants aged 0–3 years with physician-confirmed non-IgE-mediated cow's milk allergy were synthesized in this systematic review. The review, authored by Wei Kong and published on figshare in 2026, includes an integrative analysis of publicly available single-cell RNA sequencing datasets from pediatric intestinal biopsies to corroborate mechanistic pathways.

Use Cases

• Investigating the role of gut dysbiosis in food allergy pathogenesis based on the described Bifidobacterium/Enterobacteriacea ratio.
• Analyzing the AhR–TLR4 signaling pathway in intestinal epithelial cells based on the described multi-omics corroboration.
• Evaluating predictive biomarkers for allergy persistence based on the described B/E ratio and its associated hazard ratio.
• Assessing potential nutritional interventions based on the described synbiotic (LGG + HMOs) trial results.

Strengths

• Evidence synthesis follows PRISMA guidelines, incorporating 39 studies.
• Includes integrative analysis of publicly available single-cell RNA sequencing data for cellular-level corroboration.
• Reports specific predictive metrics, including a hazard ratio of 1.9 and an AUC of 0.82 for the B/E ratio.

Limitations

• The dataset is a 121.1 KB PDF document; the underlying raw data from the 39 studies or the scRNA-seq analysis is not directly provided.
• Row count and column-level documentation for any integrated data are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Systematic review authored by Wei Kong, published on figshare.

Collection Method

Synthesis of 39 studies following PRISMA guidelines, with integrated analysis of public scRNA-seq datasets.

Time Range

Studies focus on infants aged 0–3 years.

Freshness

Last updated 2026-04-14 05:39:05

Geography

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