miR-30c-5p/SOCS3 Axis Data for Duchenne Muscular Dystrophy Inflammation

Yayu Wang published a dataset on figshare in May 2026. It contains results from an integrated analysis of RNA-seq data to investigate miRNA-mRNA regulatory networks in Duchenne muscular dystrophy. The data likely includes differential expression results for miRNAs and genes, such as miR-30c-5p and SOCS3, from studies in mdx mice and cell models.

Use Cases

• Validate miRNA-mRNA regulatory network predictions based on integrated bulk and single-cell RNA-seq data.
• Analyze differential expression patterns of miRNAs and hub genes like SOCS3 in muscular dystrophy models.
• Correlate gene expression changes with inflammatory pathway enrichment and metabolic process suppression.
• Benchmark computational predictions of miRNA targets against experimental validation results from dual-luciferase assays.

Strengths

• Integrated analysis of multiple RNA-seq datasets (GSE38417, GSE109178, GSE157668, GSE213925) from public repositories.
• Experimental validation results from mdx mice, C2C12 myoblasts, and primary skeletal muscle cells are referenced.
• Specific statistical significance values (P < 0.001, P < 0.01) for expression changes are reported in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (1.9 KB), indicating limited scope, likely containing summary or key results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Integrated analysis of public RNA-seq datasets and experimental validation in mouse and cell models.

Freshness

Last updated 2026-05-22 05:35:34; freshness should be verified.