Meta-Analysis of HIF-1α and Glycemic Parameters in Type 2 Diabetes

A systematic review and meta-analysis published in 2026, aggregating data from 36 observational studies involving 5,979 patients. It evaluates associations between peripheral blood HIF-1α protein levels and glycemic parameters like fasting plasma glucose, HbA1c, fasting insulin, and HOMA-IR in individuals with type 2 diabetes. The data was compiled by Yi Su from searches across PubMed, Embase, Cochrane Library, and Chinese databases.

Use Cases

• Analyze the correlation between HIF-1α levels and fasting plasma glucose based on the meta-analysis results
• Model the relationship between HIF-1α and insulin resistance (HOMA-IR) based on the aggregated study data
• Investigate geographic variations in the HIF-1α association with glycemic outcomes based on subgroup analysis findings
• Validate HIF-1α as a potential clinical biomarker for β-cell dysfunction based on the systematic review conclusions

Strengths

• Aggregates data from 36 studies with a total sample size of 5,979 patients
• Includes results for four key glycemic parameters: FPG, HbA1c, FINS, and HOMA-IR
• Searched both English (PubMed, Embase, Cochrane, WOS) and Chinese (Wanfang, CNKI, VIP, SinoMed) databases
• Study quality was assessed using AHRQ criteria

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a single PDF file of 185.1 KB, indicating limited scope and likely summary-level data

Provenance

Source

Yi Su

Collection Method

Systematic review and meta-analysis of observational studies

Time Range

Studies searched from inception to July 28, 2025

Freshness

Last updated 2026-04-10 06:02:04