Mouse Muscle Transcriptome Data on High-Fat Diet and Exercise Intervention

RNA sequencing data from a study investigating the effects of an 8-week moderate-intensity continuous training intervention on high-fat diet-induced muscle wasting in mice. The dataset, 29.4 KB in size, was published by Weihao Hong on figshare in March 2026. It captures transcriptomic adaptations in the gastrocnemius muscle, comparing diet and exercise conditions.

Use Cases

• Identify differentially expressed genes related to muscle atrophy based on the mention of Foxo1, Fbxo32, and Trim63.
• Analyze transcriptional programs for lipid metabolism based on described enhancements in fatty acid uptake, trafficking, and β-oxidation.
• Investigate pathway enrichment in signaling cascades such as FoxO, PI3K–Akt, and MAPK based on the functional analyses described.
• Study the relationship between transcriptomic changes and physiological metrics like muscle fiber cross-sectional area and intramuscular lipid accumulation mentioned in the description.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• The underlying study design is described in detail, including a 21-week high-fat diet and an 8-week exercise intervention.
• Transcriptomic data is linked to specific physiological outcomes like grip strength and muscle index.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 29.4 KB file size suggests a limited scope, likely containing processed results rather than raw sequencing reads.

Provenance

Source

figshare, author Weihao Hong.

Collection Method

RNA sequencing of mouse gastrocnemius muscle following controlled diet and exercise interventions.

Freshness

Last updated 2026-03-18 07:34:55; freshness should be verified.