Zebrafish Larvae Transcriptomic Profiling Under Simulated Microgravity

Juan D. Carvajal-Agudelo's dataset contains transcriptomic data from zebrafish larvae exposed to simulated microgravity for up to 24 hours. The data includes gene expression analyses focusing on the RANKL/RANK/OPG pathway and other bone-related signaling pathways. It was last updated on May 4, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Modeling bone resorption dynamics based on the RANKL/RANK/OPG pathway gene expression data.
• Analyzing time-series gene expression patterns for osteoblast and osteoclast markers under simulated microgravity.
• Investigating stress-adaptive and signaling pathways (e.g., WNT, BMP, HIPPO, MAPK) involved in skeletal regulation.
• Studying the developmental stage-specific protective response of zebrafish larvae to gravitational changes.

Strengths

• Data includes a detailed time-series analysis at 6, 12, 18, and 24 hours post-exposure.
• Transcriptomic analysis covers multiple signaling pathways (WNT, BMP, HIPPO, MAPK) and stress-response genes.
• The dataset is explicitly linked to a specific biological mechanism: RANKL/RANK/OPG-mediated osteoclastogenesis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (170.8 KB), indicating a limited scope of data.

Provenance

Source

figshare, author Juan D. Carvajal-Agudelo.

Collection Method

Transcriptional responses analyzed via RT-qPCR and transcriptomic analysis of zebrafish larvae exposed to simulated microgravity using a Random Positioning Machine.

Time Range

Exposure time points of 6, 12, 18, and 24 hours.

Freshness

Last updated 2026-05-04 09:59:36; freshness should be verified.