Mouse Brain Transcriptomic Profiles for High-Altitude Injury and Oxygen Therapy

Data Sheet 3 contains transcriptomic and molecular validation data from a study by Xiaojie Hu, last updated in April 2026. The dataset includes results from a mouse model of high-altitude cerebral injury treated with normobaric or hyperbaric oxygen therapy. It likely contains gene expression data, pathway analysis results, and measurements of oxidative stress and inflammatory markers.

Use Cases

• Analyze differential gene expression patterns based on RNA-seq data mentioned in the description
• Validate pathway enrichment in NF-κB or PI3K-AKT signaling based on KEGG analysis results
• Model the relationship between oxidative stress markers (SOD, MDA) and treatment groups
• Investigate correlations between cytokine levels (IL-1β, IL-6, TNF-α) and transcriptomic changes

Strengths

• Includes multi-modal validation data from RNA-seq, Western blot, immunofluorescence, and ELISA as described
• Data is associated with a controlled animal study with four distinct experimental groups
• Released under a permissive CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (43.2 KB), suggesting it may be a summary or supplementary file rather than raw sequencing data

Provenance

Source

Xiaojie Hu via figshare

Collection Method

Data generated from a controlled laboratory study using a mouse model in a hypobaric hypoxia chamber.

Time Range

The study involved 3 days of hypoxia exposure followed by 3 days of treatment, but the overall study dates are unknown.

Freshness

Last updated 2026-04-13 05:49:15; freshness should be verified

Geography

Laboratory study; geographic location of the research institution is unknown.