PANDAS Autoantibody Screening Data from Nucleic Acid Protein Programmable Array

Autoantibody reactivity profiles from a study comparing children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) to patients with autism spectrum disorder and healthy controls. The dataset likely contains results from unbiased screening using a Nucleic Acid Protein Programmable Array (NAPPA), identifying 1,235 non-overlapping protein targets in an initial screen and 117 PANDAS-specific targets in a secondary screen. The data was uploaded by Jelena Eremija to figshare in April 2026.

Use Cases

• Identify potential autoimmune targets in PANDAS based on the unbiased screening method described.
• Compare autoantibody profiles between PANDAS, autism spectrum disorder, and healthy control groups.
• Analyze the heterogeneity of the humoral response, as 67.5% of PANDAS-positive targets were reactive in only a single patient.
• Perform functional enrichment analysis on PANDAS-specific targets, which were overrepresented among transcription factors, apoptosis regulators, and neural development proteins.
• Evaluate the diagnostic utility of autoantibody signatures for neuropsychiatric conditions, given the described challenges with cross-validation.

Strengths

• The study identified 117 autoantibody targets exclusively detected in PANDAS and absent from control groups.
• Functional enrichment analysis provides specific biological insights, highlighting overrepresentation in categories like transcription factors and chromatin modifiers.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is very small (36.8 KB), indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description notes autoantibody profiles were highly heterogeneous and no individual protein or panel achieved reliable diagnostic discrimination.

Provenance

Source

figshare

Collection Method

Unbiased screening using Nucleic Acid Protein Programmable Array (NAPPA).

Freshness

Last updated 2026-04-29 05:41:43; freshness should be verified.