Xinnaoxin Tablets: Mechanisms for High-Altitude Cardiac Injury in a Mouse Model

A 29.9 KB PDF authored by Zhihui Wang and last updated on 2026-05-28. The document describes a study investigating the multi-target mechanisms of Xinnaoxin tablets against high-altitude polycythemia and associated cardiac injury using a hypobaric hypoxia mouse model. The research employed systems pharmacology, UPLC-Q-TOF-MS metabolite identification, and multi-level physiological assessments.

Use Cases

• Study the effects of Xinnaoxin tablets on blood parameters like red blood cell count and hemoglobin based on the described experimental results.
• Analyze the modulation of signaling pathways such as NF-κB, MAPK, and PI3K/AKT in cardiac injury based on the described Western blot analyses.
• Investigate the relationship between hypobaric hypoxia, bone marrow CD71+ cells, and 'ineffective erythropoiesis' based on the described methodology.
• Examine the correlation between oxidative stress markers (MDA, SOD) and myocardial protection based on the described findings.

Strengths

• The study description includes specific, multi-faceted assessment methods such as UPLC-Q-TOF-MS, echocardiography, and Western blot analysis.
• The research employs a combined strategy of systems pharmacology and multi-level analysis, as stated in the description.
• The dataset is shared under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• The primary data file is a 29.9 KB PDF, which likely contains a research paper summary rather than the underlying raw experimental data.
• Column-level documentation for any potential tabular data is absent; field semantics must be inferred from the paper.
• The row count and data structure are unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Experimental data generated from a hypobaric hypoxia mouse model, with analyses including blood tests, histopathology, and molecular assays.

Freshness

Last updated 2026-05-28 04:53:04; freshness should be verified.