PA.Sig: Pyroptosis–Apoptosis Gene Signature for Glioma Prognosis and Immune Landscape

A transcriptomic and clinical dataset from TCGA-GBMLGG and external cohorts was used to construct a pyroptosis–apoptosis–associated gene signature (PA.Sig) for glioma. The research, authored by Huaichao Zhang and published on figshare in 2026, links this inflammatory cell death signature to patient survival, tumor cell states, and immune microenvironment dynamics. The dataset likely contains gene expression profiles and associated clinical outcomes used to stratify patients into high- and low-risk prognostic groups.

Use Cases

• Stratifying glioma patient prognosis based on the PA.Sig cell death signature described in the study.
• Analyzing associations between cell death programs and tumor immune microenvironment features like infiltration and exhaustion.
• Investigating links between specific malignant cell states (e.g., MES-like, AC/MES-like) and inflammatory death pathways.
• Modeling therapeutic response by correlating the PA.Sig risk score with genomic alteration profiles and pathway enrichment.

Strengths

• Data is derived from established sources including the TCGA-GBMLGG cohort, a standard reference in cancer genomics.
• The study includes external validation cohorts, which may support the robustness of the findings.
• Analysis integrates multiple data modalities: transcriptomics, clinical outcomes, genomic alterations, and single-cell RNA sequencing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary file is a 398.6 KB PDF, suggesting the dataset itself may be small or consist of summary results rather than raw data.

Provenance

Source

TCGA-GBMLGG and external validation cohorts, as cited in the description.

Collection Method

Transcriptomic and clinical data analysis, survival modeling, and single-cell RNA sequencing analysis.

Freshness

Last updated 2026-05-21 04:39:03; freshness should be verified.