Maternal Separation Effects on Aging Biomarkers in Middle-Aged Male Rats

Early adversity from maternal separation induces systemic aging signatures in middle-aged male rats. This dataset, published by Pratik R. Chaudhari in May 2026, contains serum biomarker measurements from an animal model of early stress. Findings include increased corticosterone, oxidative stress markers, and advanced glycation end-products, alongside reduced trophic factors and antioxidant enzyme activity.

Use Cases

• Modeling the relationship between early life stress and biological aging based on serum biomarker panels.
• Analyzing correlations between oxidative stress markers and metabolic dysregulation in an animal model.
• Investigating the long-term impact of maternal separation on trophic factor signaling and glyco-oxidative damage.

Strengths

• Dataset is openly licensed under CC-BY-4.0, facilitating reuse.
• Description details specific, measured biomarkers like corticosterone, BDNF, IGF1, Ox-LDL, SOD, catalase, triglycerides, cholesterol, LDL, AGEs, MGO, and sRAGE.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to middle-aged male rats, which may not generalize to other demographics or species.

Provenance

Source

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Collection Method

Experimental data from a rodent model of maternal separation, with serum analyzed via biochemical assays and mass spectrometry.

Time Range

The study focuses on middle-aged animals, but the exact experimental timeframe is not specified.

Freshness

Last updated 2026-05-04 04:24:30; freshness should be verified.

Geography

Geographic origin of the data or study location is unknown.