Data Sheet 4_ALDH1A1-dopaminergic gene co-expression in human substantia nigra: meta-analy

Gene expression correlation data from a meta-analysis of seven independent human substantia nigra microarray datasets, comprising 156 samples (70 controls, 86 Parkinson's disease). The dataset, created by Drake H. Harbert and last updated in May 2026, quantifies changes in co-expression between ALDH1A1 and dopaminergic pathway genes in Parkinson's disease.

Use Cases

• Validate the selective attenuation of ALDH1A1 co-expression with dopaminergic genes in Parkinson's disease based on the reported correlation changes.
• Perform secondary meta-analysis on gene correlation data from the seven referenced human substantia nigra datasets.
• Investigate the role of retinoic acid pathway disruption in neurodegenerative disease using the provided correlation statistics.
• Benchmark cell type enrichment scoring methods against the reported results from six analyzable datasets.

Strengths

• Analysis is based on seven independent human substantia nigra datasets, aggregating 156 samples.
• Results include pooled correlation estimates with heterogeneity statistics from a random-effects meta-analysis.
• Statistical significance was assessed with permutation testing (n=5,000) as a primary test.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (9.2 KB), indicating it contains summary statistics rather than raw expression data.

Provenance

Source

Gene Expression Omnibus (GEO), via figshare.

Collection Method

Meta-analysis of gene expression correlations from seven independent human substantia nigra microarray datasets.

Freshness

Last updated 2026-05-19 05:30:33; freshness should be verified.