Bat B-Cell Receptor CDR3 Repertoire Annotations and Comparative Analysis

A 2026 study by QinLu Liu provides chromosome-level annotations of immunoglobulin heavy (IGH) and light (IGK/IGL) chain loci for two bat species, Rhinolophus ferrumequinum and Antrozous pallidus. The dataset includes derived B-cell receptor (BCR) CDR3 repertoire sequences from spleen and intestinal tissues of Hipposideros armiger and Rhinolophus pearsonii/pusillus, analyzed via high-throughput sequencing. This foundational work compares bat BCR characteristics to those of humans and mice.

Use Cases

• Comparative analysis of B-cell receptor diversity based on annotated IG H/K/L gene loci.
• Studying V and J gene usage patterns in bat immune tissues based on the described CDR3 repertoires.
• Identifying species-specific motifs and amino acid distributions in CDR3 regions based on the comparative analysis with human and mouse data.
• Developing specialized bioinformatics tools for bat immunogenomics based on the provided MixCR tool framework.

Strengths

• Provides first chromosome-level annotations for bat IG loci, including specific gene counts (e.g., 81 HV, 16 HD genes in Antrozous pallidus).
• Includes comparative evolutionary analysis and high-throughput sequencing data from multiple bat species and tissues.
• Dataset is openly licensed under CC-BY-4.0 for reuse and modification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Primary data file is a DOCX document (17.1 MB), which may require extraction and conversion for computational analysis.

Provenance

Source

figshare, author QinLu Liu.

Collection Method

Chromosome-level annotation, 5'RACE, and high-throughput sequencing of BCR CDR3 repertoires.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05-20 04:34:14

Geography

Data derived from bat species including Rhinolophus ferrumequinum, Antrozous pallidus, Hipposideros armiger, and Rhinolophus pearsonii/pusillus.