Assessing Translational Relevance of Molecular Pathways in Spontaneous Lupus Mouse Models

A study integrating longitudinal molecular data from four spontaneous lupus mouse models with human SLE cohort data. The dataset, authored by María Rivas-Torrubia and last updated in May 2026, includes transcriptome sequencing from blood, spleen, and kidney, flow cytometry, and plasma measurements across four time points. It provides a framework for evaluating how mouse models recapitulate key molecular pathways of human systemic lupus erythematosus.

Use Cases

• Compare molecular pathway dysregulation across different spontaneous lupus mouse models based on the described transcriptome, flow cytometry, and plasma data.
• Assess the translational relevance of mouse models to human SLE by integrating the described mouse data with human cohort molecular signatures.
• Identify time points of interest for future experimental designs based on the described dynamics of phenotype-associated molecular signatures.
• Investigate shared immune features like interferon responses and neutrophil activation between mouse models and human disease as described.

Strengths

• Includes data from four distinct spontaneous lupus mouse models (MRL lpr/lpr, NZB/W, BXSB.Yaa, Tlr7.Tg6) enabling comparative analysis.
• Features longitudinal data collected at four time points, allowing for the study of molecular dynamics.
• Integrates multi-modal measurements including transcriptome sequencing, flow cytometry, and plasma cytokine/autoantibody levels.
• Licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The 3.6 MB file size suggests the dataset is relatively small, potentially containing summary or processed results rather than raw sequencing reads.

Provenance

Source

figshare

Collection Method

Experimental data from mouse models combined with analysis of human cohort data from the PRECISESADS study.

Freshness

Last updated 2026-05-13 05:58:20