Environmental E. coli Strains: Colistin Resistance and Oxidant Tolerance Measurements

Several E. coli strains isolated from mixed wastewater, characterized for resistance to the last-resort antibiotic colistin and tolerance to DNA-damaging agents. The dataset includes IC50 values for colistin ranging from 6.5 to 27.3 μg/mL, genomic analysis revealing the mcr-1 gene and mutations in DNA repair genes, and phenotypic data on resistance to other antibiotics and hydrogen peroxide. It was authored by Asmaa Al-Mesaifri and last updated in June 2026.

Use Cases

• Modeling the relationship between mcr-1 gene presence and colistin IC50 values based on the reported resistance measurements.
• Analyzing co-resistance patterns to antibiotics like ciprofloxacin, sulfamethoxazole, and tetracycline in environmental isolates.
• Investigating genetic mutations linked to oxidant tolerance based on the described whole genome sequencing data of H2O2-resistant strains.
• Studying the correlation between DNA fragmentation under H2O2 stress and the observed phenotypic resistance in the characterized strains.

Strengths

• Quantitative IC50 values for colistin resistance are provided, with a specific range from 6.5 to 27.3 μg/mL.
• Includes multi-faceted characterization combining phenotypic antibiotic resistance, oxidant tolerance, and whole genome sequencing data.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• The dataset is very small at 11.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

Asmaa Al-Mesaifri via figshare.

Collection Method

E. coli strains were isolated from mixed wastewater and characterized through laboratory assays and whole genome sequencing.

Freshness

Last updated 2026-06-02 22:02:20; freshness should be verified.