Data Sheet 4_Clinical predictors of BRCA1/2 P/LP variants for high-risk breast cancer pati

From 2017 to 2021, this dataset contains clinical data from 1,204 high-risk breast cancer patients at Zhejiang Cancer Hospital in eastern China. It was created by Wei Gu to develop a model predicting BRCA1/2 pathogenic variant carrier status based on histology, molecular subtype, age, and family history. The model achieved an AUC of 0.758 and was validated with 500 bootstrap resamples.

Use Cases

• Training a logistic regression model to predict BRCA1/2 carrier status based on clinical features like histology and family history.
• Analyzing the association between triple-negative breast cancer (TNBC) and BRCA1/2 variant prevalence in a high-risk cohort.
• Validating clinical prediction models using bootstrap resampling and decision curve analysis (DCA) techniques.
• Benchmarking the performance of clinicopathology-based models against genetic testing 'test-all' strategies.

Strengths

• Includes 1,204 patient records from a defined high-risk cohort in China.
• Model performance is quantified with specific metrics: AUC of 0.758, Brier score of 0.071, and bootstrap validation with 500 resamples.
• Data provenance is clear, sourced from Zhejiang Cancer Hospital with targeted NGS for BRCA1/2.
• Missing data was addressed using Multiple Imputation by Chained Equations (MICE).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying clinical data table is unknown, which may limit suitability assessment.
• The dataset is small in file size (155.4 KB), suggesting limited scope or a summary document rather than raw patient-level data.

Provenance

Source

Zhejiang Cancer Hospital, eastern China.

Collection Method

Clinical data collection and targeted next-generation sequencing (NGS) for BRCA1/2, with variant classification by ClinVar and ACMG-AMP guidelines.

Time Range

2017–2021

Freshness

Last updated 2026-06-02 04:21:27; freshness should be verified.

Geography

Eastern China