CLL Cell-Derived Soluble Factors and Normal B Cell Functionality

Data Sheet 4 by Michelle Maria Elbert investigates the hypothesis that soluble factors from chronic lymphocytic leukemia cells impair normal B cell function. The dataset includes results from in vitro functional B-cell assays measuring plasma cell differentiation, proliferation, cell death, and activation markers. It was last updated on May 15, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Testing the influence of CLL patient serum on B-cell activation based on CD80, CD86, and CD25 marker measurements.
• Comparing B-cell proliferation and cell death levels between CLL-conditioned medium and healthy control medium.
• Analyzing plasma cell differentiation in normal B cells after T-cell-dependent stimulation in different culture conditions.

Strengths

• The dataset is associated with a clearly defined research hypothesis and experimental method.
• It is shared under a permissive CC-BY-4.0 license, facilitating reuse.
• The description specifies measured outcomes including proliferation, cell death, and activation markers.

Limitations

• The dataset is small (161.1 KB), suggesting limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Michelle Maria Elbert via figshare.

Collection Method

Functional B-cell assays using serum from CLL patients and conditioned medium from CLL cells cultivated with stromal cells.

Freshness

Last updated 2026-05-15 05:52:09; freshness should be verified.