TRIM28-MAVS Ubiquitination Data from Antiviral Signaling Study

A 22.0 MB dataset from a 2026 study by Ruihua Xin on the TRIM28-MAVS axis in antiviral immunity. The data supports findings that TRIM28 promotes K48-linked ubiquitination of MAVS to suppress RIG-I signaling. It includes results from confocal microscopy, co-immunoprecipitation, and in-cell ubiquitination assays.

Use Cases

• Analyze confocal microscopy data to quantify virus-induced nucleocytoplasmic trafficking of TRIM28.
• Use co-immunoprecipitation results to model protein interactions between TRIM28, MAVS, and CRM1.
• Examine in-cell ubiquitination assay data to validate K48-linked polyubiquitination events on MAVS.
• Correlate TRIM28 knockdown/overexpression data with type I IFN response levels and RNA virus replication metrics.
• Assess data from MAVS lysine mutants (K136, K461) to identify functionally relevant ubiquitination sites.

Strengths

• Data is directly tied to a 2026 peer-reviewed research publication, ensuring scientific relevance.
• Includes results from multiple experimental methods: confocal microscopy, co-immunoprecipitation, and in-cell ubiquitination assays.
• Released under a permissive CC BY 4.0 license, allowing for reuse and redistribution.

Limitations

• The dataset is small (22.0 MB), indicating it likely contains processed results and figures rather than large-scale raw data.
• Specific data structure, column names, and row counts are unknown, complicating direct programmatic analysis.
• Data is focused on a specific molecular pathway (TRIM28-MAVS), limiting broader biological applications without integration.

Provenance

Source

Ruihua Xin, via the figshare repository.

Collection Method

Generated through laboratory experiments including TRIM28 overexpression/knockdown, confocal microscopy, co-immunoprecipitation, and ubiquitination assays.

Time Range

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Freshness

Last updated on 2026-03-24, indicating recent data from a forward-dated publication.

Geography

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