Gut Microbiome and Mycobiome in Ulcerative Colitis Across Paediatric and Adult Patients

73 targeted bacterial and 69 targeted fungal metagenomes from 26 paediatric and 47 adult patients with ulcerative colitis, analyzed in a study by Francesca Toto. The dataset was last updated on 2026-04-28. It includes microbial diversity metrics, mucosal immune markers, and clinical variables like disease activity and treatment exposure.

Use Cases

• Comparing fungal versus bacterial community richness across life stages based on the described alpha- and beta-diversity analyses.
• Identifying age-associated immune patterns based on lysozyme and sIgA levels mentioned in the results.
• Investigating dysbiosis in young adults based on described Basidiomycota/Ascomycota and Firmicutes/Bacteroidota ratios.
• Analyzing correlations between specific fungal taxa (e.g., Saccharomycetes, Clavispora) and disease characteristics across age groups.

Strengths

• Includes 142 total metagenomic samples (73 bacterial, 69 fungal) from a defined cohort of 73 patients.
• Clinical variables such as disease activity, duration, and treatment exposure were considered in the analysis.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small in size (68.6 KB), suggesting limited scope or summary-level data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Francesca Toto via figshare

Collection Method

Targeted metagenomic sequencing of gut bacteria and fungi from patient samples, with immune markers assessed by ELISA.

Freshness

Last updated 2026-04-28 05:28:22; freshness should be verified.