Murine Shock/Sepsis Lung Injury Data on PD-L1 Knockout Models

Elizabeth W. Tindal's research data compares survival and biomarker outcomes in genetically modified mice lacking PD-L1 on endothelial cells or neutrophils. The dataset includes 14-day mortality rates, lung permeability measurements, and cytokine/chemokine levels from bronchoalveolar lavage fluid, blood, and lung tissue. Data was collected from mice subjected to hemorrhagic shock and cecal ligation and puncture procedures.

Use Cases

• Modeling the differential impact of cell-specific PD-L1 deficiency on sepsis mortality based on survival study results.
• Analyzing lung injury severity based on lung vascular permeability and Evan’s Blue dye exclusion data.
• Correlating cytokine levels (e.g., MCP-1, MIP-2, IL-6, Angiopoietin 2) with specific genetic knockouts and injury outcomes.
• Investigating immune cell function by comparing outcomes from endothelial cell versus neutrophil PD-L1 knockout models.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific genetic analysis.
• Includes multiple biological sample types: peripheral blood, bronchoalveolar lavage fluid, and lung tissue.
• Measures a range of outcomes: survival, vascular permeability, and specific cytokine/chemokine levels.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 163.0 KB size suggests a limited scope, likely containing summary results rather than raw high-throughput data.

Provenance

Source

Elizabeth W. Tindal via figshare

Collection Method

Experimental data from mouse models subjected to hemorrhagic shock and cecal ligation and puncture, with samples analyzed by flow cytometry and ELISA.

Freshness

Last updated 2026-06-02 04:28:46; freshness should be verified