Epimedium Effects on Alzheimer's Disease in Rats: KAT2B and Neuroinflammation Data

A figshare dataset by Jie Gao, last updated in April 2026, containing results from a study on the herb Epimedium's effects on Alzheimer's disease. The 126.6 KB Excel file likely includes data on 172 identified key targets, cognitive function assessments, and cytokine levels from an in vivo rat model. The study investigated the modulation of neuroinflammation through the core gene KAT2B.

Use Cases

• Analyzing the relationship between KAT2B expression and cognitive deficits based on the described in vivo model.
• Investigating the correlation between IL-1β/TNF-α cytokine levels and histopathological damage in hippocampal neurons.
• Studying the predicted interaction network of 172 key targets associated with Epimedium and Alzheimer's disease.
• Validating transcriptomic screening results for core genes like KAT2B and ACACB in an Alzheimer's disease context.

Strengths

• Data is derived from a described experimental model combining AlCl3 and D-galactose administration.
• Includes multiple measurement types: cognitive assessment (Morris water maze), histopathology (H&E staining), cytokine detection (ELISA), and gene expression (qRT-PCR).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (126.6 KB), indicating limited scope or a summary of results rather than raw experimental data.

Provenance

Source

figshare, author Jie Gao.

Collection Method

Data likely generated from laboratory experiments on a rat model of Alzheimer's disease, as described.

Time Range

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Freshness

Last updated 2026-04-20 04:12:09; freshness should be verified.

Geography

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