Gene Expression and lncRNA Network in Primary Sjögren's Syndrome

126 salivary gland samples from patients and controls were sequenced for a genome-wide transcriptome analysis. The dataset likely contains expression data for coding and noncoding genes, used to construct a competing endogenous RNA network with 3,035 lncRNAs and 10,838 coding genes. Author Zhongshan Li published this research on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Constructing competing endogenous RNA (ceRNA) networks based on shared miRNA binding sites and gene expression correlations.
• Identifying differentially expressed genes between disease and control groups for biomarker discovery.
• Predicting regulatory roles of long noncoding RNAs (lncRNAs) based on their interacting coding genes.
• Validating lncRNA function through in vitro experiments, as described for BISPR, LINC00926, and HCP5.

Strengths

• Includes 126 total samples (92 patients, 34 controls), providing a basis for statistical comparison.
• The constructed ceRNA network is genome-wide, comprising 3,035 lncRNAs and 10,838 coding genes.
• Experimental validation was performed for three key lncRNAs, linking them to clinical features.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (863.5 KB), suggesting it may contain summary results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:18; freshness should be verified.

Geography

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