Data Sheet 4_Glucagon-like peptide-1 receptor agonists and advanced liver outcomes in type

A systematic review and exploratory meta-analysis of 12 comparative real-world cohort studies investigating the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and advanced liver outcomes in adults with type 2 diabetes. The work was authored by Jing-Hong Hu and published on figshare in June 2026 under a CC-BY-4.0 license. The primary pooled estimate from four active-comparator studies was a hazard ratio of 0.85 for incident cirrhosis or composite serious liver events.

Use Cases

• Conducting a secondary analysis of the pooled hazard ratios and confidence intervals reported in the meta-analysis.
• Reviewing the methodology for a systematic review focused on real-world evidence and active-comparator designs.
• Assessing the certainty of evidence and limitations described for observational studies on drug outcomes.
• Examining the study selection and evidence-identification strategy for a focused, non-exhaustive review.

Strengths

• Includes a specific, pre-registered systematic review protocol (PROSPERO CRD420261299499).
• Reports a primary pooled hazard ratio (HR 0.85) with confidence intervals from a meta-analysis of four studies.
• Explicitly details the search strategy, including an update through April 2026, and the inclusion of 12 eligible studies.

Limitations

• The dataset is a 10.9 KB DOCX document, indicating a very limited textual summary rather than the underlying study data.
• Row count and column-level documentation are absent; the file contains analysis results and narrative, not structured data tables.
• The authors rate the certainty of evidence as 'very low' due to the observational nature of included studies and potential residual confounding.

Provenance

Source

figshare, authored by Jing-Hong Hu.

Collection Method

Systematic review and exploratory meta-analysis of peer-reviewed comparative real-world cohort studies identified via PubMed/MEDLINE and Embase.

Time Range

Literature search updated through 25 April 2026.

Freshness

Last updated 2026-06-02 04:21:25.