Diabetic Nephropathy and Retinopathy Common Gene Analysis from GSE185011

206 common genes were identified by intersecting differentially expressed genes from diabetic nephropathy and diabetic retinopathy transcriptome data. The study, authored by Juan He and last updated in April 2026, screened 6 diagnostic genes for DN and 4 for DR, including ATP4A which appears in both. It further constructed TF-mRNA-miRNA regulatory networks and analyzed immune cell infiltration differences between the conditions.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 screened genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic complications using the 206 common genes.
• Analyzing immune cell infiltration patterns, such as the decreased central memory CD4 T cells in DN groups mentioned in the results.
• Studying gene regulatory networks for diabetic retinopathy based on the constructed 111 TF-4mRNA-33miRNA network.

Strengths

• Identifies a specific set of 206 common genes between two diabetic complications.
• Screens and lists specific diagnostic gene candidates, including 6 for DN and 4 for DR.
• Includes analysis of immune cell infiltration and constructed regulatory networks (e.g., 493 TF-6mRNA-183miRNA for DN).

Limitations

• The dataset is very small at 119.2 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

Transcriptome data from GSE185011, analyzed by Juan He and shared on figshare.

Collection Method

Bioinformatic analysis using differential expression screening (limma), enrichment analyses (ClusterProfiler, Metascape), LASSO, and immune cell infiltration analysis.

Freshness

Last updated 2026-04-28 05:24:44; freshness should be verified.