Data Sheet 4_Insights into the effects of gut microbiota and circulating metabolites on or

A dataset containing results from a bidirectional two-sample Mendelian randomization analysis investigating causal links between gut microbial taxa, circulating metabolites, and oral cancer. The data includes associations for 471 gut microbial taxa and 233 circulating metabolites derived from genome-wide association studies, with findings validated by clinical multi-omics profiling. It was authored by Junfeng Guo and last updated on 2026-05-21.

Use Cases

• Identify potential causal gut microbial taxa for oral cancer based on odds ratios and p-values.
• Investigate the mediating role of specific circulating metabolites like citrate and omega-3 fatty acids in the gut-oral cancer link.
• Validate Mendelian randomization findings using the described clinical multi-omics profiling data.
• Explore genetic instrument data from genome-wide association studies for 471 microbial taxa and 233 metabolites.

Strengths

• Analysis includes data for 471 gut microbial taxa and 233 circulating metabolites.
• Results are based on multiple Mendelian randomization methods, including IVW-MR and GSMR, with supplementary analyses.
• Findings were validated with additional clinical samples and multi-omics profiling.
• Released under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• The dataset is small (198.5 KB), suggesting it contains summary results rather than raw GWAS data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

Data derived from genome-wide association studies for gut microbiota, circulating metabolites, and oral cancer.

Collection Method

Bidirectional two-sample Mendelian randomization analysis with clinical validation.

Freshness

Last updated 2026-05-21 05:45:51; freshness should be verified.