Integrated Stress Response Gene Biomarkers for Ankylosing Spondylitis

39.6 KB Excel file contains transcriptomic and Mendelian randomization results identifying novel biomarkers for ankylosing spondylitis. Author Shuai Wang's study, updated March 2026, validated downregulation of RORA and FBXO31 and upregulation of MSRB3 in patient blood samples. The data supports causal inference and drug prediction analyses.

Use Cases

• Validate the causal association between ISR-related genes like RORA, FBXO31, MSRB3 and AS susceptibility using Mendelian randomization results.
• Perform functional enrichment analysis on differentially expressed genes to investigate involvement in olfactory transduction pathways.
• Correlate gene expression signatures with immune infiltration data, particularly for Th1 cells and keratinocytes.
• Use drug prediction results to evaluate potential therapeutic agents such as indirubin and pentoxifylline.

Strengths

• Includes RT–qPCR validation of candidate biomarkers in clinically collected blood samples.
• Integrates multiple analytical methods: transcriptomic profiling, Mendelian randomization, functional enrichment, and drug prediction.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is very small at 39.6 KB, indicating limited scope and likely a summary of results rather than raw data.
• Unknown row and column counts prevent assessment of data volume and feature completeness.
• Lacks sample data and column definitions, requiring users to infer structure from the Excel file.

Provenance

Source

figshare, author Shuai Wang.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, Mendelian randomization analysis, followed by RT–qPCR validation.

Time Range

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Freshness

Last updated March 2026.

Geography

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