Plasma Exosomal Proteomics Data for Thyroid Disorders and Papillary Carcinoma

A 2026 study by Yawei Zhang identified plasma exosomal biomarkers for papillary thyroid carcinoma (PTC) in patients with Hashimoto’s thyroiditis (HT). The dataset includes proteomic analysis results from plasma samples of patients with PTC, PTC with HT, HT, and healthy controls. It contains 45 differentially expressed proteins validated via parallel reaction monitoring.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on differential expression analysis.
• Investigate immune response pathways in thyroid disorders based on functional enrichment analysis of exosomal proteins.
• Validate potential biomarkers like SVEP1 and IGKV3-7 for non-invasive clinical diagnosis.
• Study the progression from Hashimoto’s thyroiditis to papillary thyroid carcinoma using proteomic profiles.

Strengths

• Includes validation results via parallel reaction monitoring (PRM) for two key proteins.
• Focuses on a specific clinical scenario: PTC complicating Hashimoto’s thyroiditis.
• Data is openly licensed under CC-BY-4.0.

Limitations

• Dataset scale is limited, with a file size of 167.6 KB suggesting a small scope.
• Row and column counts are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Exosome isolation and label-free quantitative proteomics performed on plasma samples from patients and controls.

Freshness

Last updated 2026-05-25 04:45:01.