Lung scRNA-seq Data from Osteogenesis Imperfecta Mouse Model

Jennifer Zieba's dataset contains single-cell RNA sequencing data from lung tissues of Col1a1^Aga2/+ (Aga2) mice, a model for osteogenesis imperfecta. The data, last updated in March 2026, reveals cellular mechanisms underlying pulmonary complications, including chronic inflammation and an emphysematous phenotype. It is a 13.6 MB XLSX file shared under a CC-BY-4.0 license.

Use Cases

• Identify cell type-specific gene expression changes based on scRNA-seq data from OI model lungs.
• Analyze pathways related to chronic inflammation, such as IL1B and TNF activation, mentioned in the description.
• Study alveolar cell transition dynamics (AT2 to AT1) in a disease context.
• Investigate fibroblast activation and differentiation patterns in diseased lung tissue.
• Examine the role of Scgb1a1 expression across immune, epithelial, and fibroblast cells in lung pathology.

Strengths

• Data is derived from a specific genetic mouse model (Col1a1^Aga2/+) recapitulating a moderate form of osteogenesis imperfecta.
• Includes samples from both young and adult mice, allowing for developmental stage comparisons.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data is specific to a mouse model; direct applicability to human OI may require further validation.
• The 13.6 MB file size suggests a relatively small-scale dataset.

Provenance

Source

Jennifer Zieba via figshare.

Collection Method

Single-cell RNA sequencing (scRNAseq) of lung tissues from a genetically modified mouse model.

Time Range

The dataset's temporal coverage is not explicitly stated.

Freshness

Last updated 2026-03 17 13:07:52.

Geography

The dataset's spatial coverage is not explicitly stated.