Meta-Analysis Data on HIF-1α and Glycemic Parameters in Type 2 Diabetes

A systematic review and meta-analysis of 36 observational studies involving 5,979 patients with type 2 diabetes. The data, compiled by Yi Su and published in 2026, evaluates associations between peripheral blood HIF-1α protein expression levels and glycemic parameters like fasting plasma glucose, HbA1c, fasting insulin, and HOMA-IR.

Use Cases

• Validate the association between HIF-1α levels and fasting plasma glucose based on the meta-analysis results
• Investigate the relationship between HIF-1α and glycated hemoglobin (HbA1c) for clinical risk assessment
• Analyze the correlation between HIF-1α and fasting insulin (FINS) levels in diabetic populations
• Model the link between HIF-1α and insulin resistance using the homeostatic model assessment (HOMA-IR) data
• Perform subgroup analysis on the effect of geographic location on the HIF-1α-FPG association

Strengths

• Includes data from 36 studies with a total sample size of 5,979 patients
• Analyzes four key glycemic parameters: FPG, HbA1c, FINS, and HOMA-IR
• Sources data from eight major databases including PubMed, Embase, and Chinese repositories

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a 76.1 KB PDF, which suggests limited scope and may require extraction

Provenance

Source

Yi Su

Collection Method

Data extracted from observational studies via systematic review and synthesized using random-effects meta-analysis.

Time Range

Studies searched from inception to July 28, 2025.

Freshness

Last updated 2026-04-10 06:02:06

Geography

Studies include Chinese and English publications; subgroup analysis indicated geographic location as a modifying factor.