Mouse Brain Transcriptomic Profiles for High-Altitude Cerebral Injury and Oxygen Therapy

A 45.6 KB PDF data sheet from a study by Xiaojie Hu, last updated April 2026, details RNA sequencing results from a mouse model of high-altitude cerebral injury. The study compares the effects of normobaric and hyperbaric oxygen therapy on gene expression, oxidative stress, and neuroinflammation pathways. Data includes results from RNA-seq, Western blot, immunofluorescence, and ELISA analyses.

Use Cases

• Analyze transcriptomic changes in response to hypoxia based on RNA-seq data mentioned in the description
• Compare the efficacy of different oxygen therapies based on pathway enrichment analysis for NF-κB, PI3K-AKT, and IL-17 signaling
• Validate oxidative stress markers based on measured levels of SOD, MDA, GSH, and NO
• Investigate neuroinflammatory responses based on cytokine levels (IL-1β, IL-6, TNF-α) and glial cell activation data

Strengths

• Data is associated with a detailed experimental protocol using a simulated altitude of 7,000m and defined oxygen therapy regimens
• Includes multi-modal validation through RNA-seq, histopathology, protein analysis, and cytokine assays
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• The dataset is very small at 45.6 KB, indicating limited scope, likely containing summary results rather than raw sequencing data
• Data is contained within a PDF, which may require extraction for computational analysis

Provenance

Source

Xiaojie Hu via figshare

Collection Method

Generated from a controlled laboratory study using a hypobaric hypoxia chamber on mice, followed by transcriptomic and biochemical analysis.

Time Range

The study period is not specified, but the dataset was updated in April 2026.

Freshness

Last updated 2026-04 13 05:49:14

Geography

Not specified; likely from a research institution's laboratory.