Whole-Exome Sequencing Data for Semen Quality Across Three Russian Ethnic Groups

157 whole-exome sequenced samples from a Russian multiethnic population study of male fertility. The dataset includes samples from three ethnic groups—Slavs (59), Buryats (49), and Yakuts (49)—categorized by semen quality as normospermia (62) or pathozoospermia (95). Author Semyon Kolmykov published the data on figshare under a CC-BY-4.0 license, with a last update in April 2026.

Use Cases

• Identifying genetic variants associated with impaired semen quality based on whole-exome sequencing data.
• Comparing allele frequencies and genetic associations across different ethnic groups (Slavs, Buryats, Yakuts).
• Prioritizing candidate genes expressed in the testis for functional studies of spermatogenesis.
• Validating potential SNP markers for male fertility in independent population cohorts.

Strengths

• Includes 157 whole-exome sequenced samples with defined ethnic and clinical groupings.
• Focuses on a specific phenotype (semen quality) with clear diagnostic criteria (WHO standards).
• Identifies nine specific SNP markers in seven testis-expressed genes for further study.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is relatively small (3.7 MB), which may limit statistical power for rare variant discovery.

Provenance

Source

figshare, author Semyon Kolmykov.

Collection Method

Whole-exome sequencing performed on 157 samples, with variant calling and filtering according to GATK Best Practices.

Freshness

Last updated 2026-04-09 03:03:41; freshness should be verified.

Geography

Russian Federation, specifically samples from Slavic, Buryat, and Yakut ethnic groups.