Meta-Analysis of DNA Repair Gene Polymorphisms and Expression in Leukemia

Data Sheet 5_A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia.docx is a 434.2 KB document authored by Honghui Ye and last updated on 2026-04-23. It contains results from a meta-analysis of 54 studies on the association between DNA repair gene polymorphisms and leukemia risk, supplemented by gene expression analyses from public datasets.

Use Cases

• Identify leukemia risk-associated polymorphisms based on meta-analysis results for genes like XPD and XRCC1.
• Analyze subtype-specific gene expression patterns of DNA repair genes mentioned in the description.
• Validate potential biomarkers for leukemia risk stratification based on the reported significant associations.
• Compare genetic association models (e.g., homozygous, dominant) for polymorphisms like ERCC1 8092C>A.

Strengths

• The analysis is based on a systematic review of 54 studies from multiple databases.
• Results include specific significant associations for polymorphisms like XPD Lys751Gln and XRCC1 Arg399Gln.
• Gene expression analysis was performed across multiple public datasets (Leukemia DB, GEPIA2, BloodSpot).
• The document is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 434.2 KB DOCX file; the underlying structured data (e.g., column-level results) is not directly accessible.
• Row count and column definitions are unknown, requiring manual inspection after download.
• The description is detailed but does not specify the exact format or granularity of the included data tables.

Provenance

Source

figshare, author Honghui Ye.

Collection Method

Systematic literature search and meta-analysis, combined with gene expression profiling from public databases.

Time Range

Literature search conducted until December 3, 2025.

Freshness

Last updated 2026-04-23 04:21:51.

Geography

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