Standardized Rat Model of Maxillary Anterior Periodontal Soft Tissue Defect

A research paper describing a standardized, minimally invasive rat model for periodontal soft tissue defect. The study, authored by Ruoxuan Huang and published on figshare in April 2026, details the creation of a 4 × 2 mm defect and its evaluation through clinical observation and histological analyses.

Use Cases

• Evaluating healing patterns and tissue integration of graft materials based on the described clinical and histological assessment methods.
• Screening soft tissue graft materials for angiogenesis and immune response based on the model's dynamic evaluation capability.
• Comparing the performance of autografts versus xenografts based on the distinct healing patterns observed in the study.
• Optimizing biomaterials for periodontal soft tissue reconstruction prior to large-animal studies based on the model's translational relevance.

Strengths

• Describes a standardized 4 × 2 mm defect model with reported low complication rates and high reproducibility.
• Includes evaluation through sequential clinical observation, H&E staining, Masson’s trichrome staining, and immunohistochemical analyses.
• Published under a permissive CC-BY-4.0 license allowing reuse and modification.

Limitations

• The dataset is a PDF document (8.1 MB); the underlying raw experimental data (e.g., measurements, images) is not directly provided.
• Column-level documentation is absent; field semantics must be inferred from the paper's text.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Experimental research involving anatomical assessment, surgical defect creation, and histological analysis in a rat model.

Time Range

The study's publication date is 2026; the experimental timeframe is not specified.

Freshness

Last updated 2026-04-20 05:23:09; freshness should be verified.

Geography

The geographic origin of the research or data collection is not specified.