CLL Cell-Derived Soluble Factors and Normal B Cell Functionality

Data Sheet 5 presents results from in vitro functional B-cell assays investigating the influence of soluble factors from chronic lymphocytic leukemia (CLL) cells on normal B cells. The dataset, authored by Michelle Maria Elbert and last updated in May 2026, includes measurements of plasma cell differentiation, proliferation, cell death, and B-cell activation markers CD80, CD86, and CD25. The analysis suggests no major direct inhibitory effects of CLL-derived soluble factors on normal mature B cells.

Use Cases

• Comparing B-cell activation levels based on CD80, CD86, and CD25 marker expression.
• Analyzing plasma cell differentiation rates under different serum conditions.
• Investigating correlations between proliferation and cell death measurements in co-culture assays.
• Testing hypotheses about the role of soluble factors in CLL-associated immunodeficiency.

Strengths

• Includes control data from healthy individuals for comparison.
• Measures multiple functional endpoints: plasma cell differentiation, proliferation, cell death, and activation.

Limitations

• Dataset scale is limited to 165.4 KB, suggesting a small sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Michelle Maria Elbert via figshare.

Collection Method

Functional B-cell assays using serum from CLL patients and conditioned medium from CLL cells cultivated with stromal cells.

Freshness

Last updated 2026-05-15 05:52:09; freshness should be verified.