Murine Shock/Sepsis Lung Injury Data on PD-L1 Knockout Impact

A 160.9 KB dataset from a 2026 study by Elizabeth W. Tindal, shared on figshare. It contains results from an experimental study on hemorrhagic shock and sepsis-induced lung injury in mice. The data compares morbidity, mortality, and biomarker levels between mice lacking PD-L1 on endothelial cells versus neutrophils.

Use Cases

• Compare survival outcomes based on cell-specific PD-L1 knockout status mentioned in the description
• Analyze lung vascular permeability changes associated with endothelial cell PD-L1 deficiency
• Investigate correlations between cytokine/chemokine levels (e.g., MCP-1, MIP-2, IL-6) and specific genetic knockouts
• Model the differential impact of PD-L1 on endothelial cells versus neutrophils on organ injury

Strengths

• Data is from a controlled laboratory experiment using Cre-lox mouse models, allowing for cell-type-specific conclusions.
• Includes multiple measured endpoints: survival, lung permeability, and cytokine/chemokine/angiopoietin levels from blood, BALF, and lung tissue.
• Shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 160.9 KB, indicating limited scope and likely a summary of key results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the PDF description.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

Elizabeth W. Tindal via figshare

Collection Method

Laboratory experiment using C57BL/6 mice subjected to hemorrhagic shock and cecal ligation and puncture (CLP). Data collected via flow cytometry, ELISA, and organ injury assays.

Freshness

Last updated 2026-06-02 04:31:28; freshness should be verified.