Murine Shock/Sepsis Lung Injury Data: PD-L1 Knockout Impact

Elizabeth W. Tindal published data on 2026-06-02 investigating the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The dataset includes results from Cre-lox mouse models with PD-L1 knocked out in endothelial cells or neutrophils, measuring survival, lung permeability, and cytokine levels. The 160.9 KB PDF file contains data from flow cytometry, ELISA assays, and organ injury indices.

Use Cases

• Compare survival outcomes based on cell-specific PD-L1 knockout status described in the study.
• Analyze correlations between lung vascular permeability and cytokine/chemokine levels measured in BALF and tissue.
• Investigate the differential impact of endothelial versus neutrophil PD-L1 on markers like MCP-1, Angiopoietin 2, and IL-6.
• Model the relationship between shock/sepsis intervention (Hem/CLP) and subsequent organ injury assays.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-specific genetic analysis.
• Includes multiple measurement types: survival studies, flow cytometry, ELISA for cytokines/chemokines/angiopoietins, and lung permeability assays.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset scale is limited at 160.9 KB; row count and sample size are unknown.
• Column-level documentation is absent; field semantics must be inferred from the PDF description.
• Data may reflect bias inherent to the specific experimental murine model used.

Provenance

Source

Elizabeth W. Tindal via figshare

Collection Method

Experimental data from murine models subjected to hemorrhagic shock and cecal ligation and puncture (CLP).

Freshness

Last updated 2026-06-02 04:28:48; freshness should be verified.