Primary Sjögren's Syndrome Gene Expression Data from 126 Salivary Gland Samples

Deep stranded total transcriptome sequencing data from 126 minor salivary gland samples, comprising 92 patients with primary Sjögren's syndrome and 34 non-SS controls. The dataset includes genome-wide coding and noncoding gene expression, a constructed competing endogenous RNA network, and in vitro validation results. It was authored by Zhongshan Li, shared under a CC-BY-4.0 license, and last updated in April 2026.

Use Cases

• Constructing competing endogenous RNA networks based on shared miRNA binding sites and gene expression correlations.
• Identifying differentially expressed genes between pSS and control groups based on transcriptome sequencing.
• Predicting regulatory roles of lncRNAs by examining expression changes of interacting lncRNAs and coding genes.
• Validating candidate lncRNA functions through in vitro experiments in a salivary gland cell line.

Strengths

• Includes data from 126 total samples (92 pSS patients and 34 controls), providing a basis for comparative analysis.
• Contains a constructed genome-wide ceRNA network comprising 3,035 lncRNAs and 10,838 coding genes.
• In vitro validation of regulatory effects for three key lncRNAs (BISPR, LINC00926, HCP5) is described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 1.7 MB PDF, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland biopsy samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:18; freshness should be verified.

Geography

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