Laron Mouse Liver RNA-seq Data from GH Receptor Gene Therapy Study

448 genes showed significant expression changes in the livers of GH-resistant mice following liver-specific GH receptor gene therapy. The dataset comprises RNA-seq data from male and female mice across four groups: wild-type, GHR-/- (Laron), treated GHR-/-, and vector control GHR-/-. Joshua K. Tay published the data on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Analyzing sex-biased gene expression patterns based on the enrichment for sex-biased genes noted in the description.
• Studying the partial restoration of IGF signaling based on the reported 16-fold upregulation of Igf1 and Igfals genes.
• Investigating potential oncogenic side effects based on the upregulation of proto-oncogenes like Ascl1 and Tmprss4 mentioned in the results.
• Comparing gene expression dysregulation between genetic knockout and therapeutic rescue models based on the 448 vs. 2781 differentially expressed genes.

Strengths

• Includes a control group treated with a Luciferase vector, where only four genes showed differential expression, indicating minimal vector effect.
• Reports specific fold-change values, such as the 16-fold induction of Igf1 and Igfals genes.
• Data is licensed under CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (66.8 KB), indicating limited scope, likely containing summary results rather than raw sequencing reads.

Provenance

Source

Joshua K. Tay via figshare.

Collection Method

RNA sequencing (RNA-seq) performed on mouse liver tissue from genetically modified and treated groups.

Freshness

Last updated 2026-05-28 04:56:28; freshness should be verified.