Data Sheet 5: Shared APC Neoantigen Design for RNA Cancer Vaccination

Over 80% of colorectal cancer cases are linked to mutations in the APC gene. Alfred J. Simmons used bioinformatics to identify shared neoantigen epitopes from this gene's mutational cluster region and tested a self-amplifying RNA vaccine candidate in a mouse model. The dataset, last updated in June 2026, serves as proof-of-concept for an APC-targeted cancer vaccine.

Use Cases

• Identifying shared neoantigen epitopes based on the described mutational cluster region of the APC gene.
• Designing cancer vaccine constructs based on the described chimeric virus-like particle and self-amplifying RNA replicon.
• Evaluating in vivo immune responses based on the described serum IgG titer measurements from BALB/c mice.

Strengths

• The description provides a specific biological target (APC gene mutations) and a clear experimental method.
• The file is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The dataset is a 557.8 KB PDF file; the underlying structured data (e.g., epitope sequences, IgG titer values) is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the PDF text.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Bioinformatics analysis and in vivo mouse model experiments, as described.

Freshness

Last updated 2026-06-04 05:19:34