Common Genes in Diabetic Nephropathy and Retinopathy from Transcriptome Data GSE185011

A transcriptomics study by Juan He, last updated in April 2026, identifies common and diagnostic genes for diabetic nephropathy (DN) and diabetic retinopathy (DR). The analysis is based on the GSE185011 dataset, intersecting 526 and 1,059 differentially expressed genes to find 206 common genes. It further identifies 6 diagnostic genes for DN and 4 for DR, including ATP4A which is common to both.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared pathogenic pathways between diabetic nephropathy and retinopathy based on the 206 common genes.
• Constructing regulatory networks for diabetic complications based on the described TF-mRNA-miRNA interactions.
• Analyzing immune cell infiltration differences in diabetic complications, as the description notes changes in central memory CD4 T cells and activated B cells.

Strengths

• Identifies specific counts of genes: 206 common genes from 526 and 1,059 differentially expressed gene sets.
• Lists concrete diagnostic gene names for both conditions: 6 for DN and 4 for DR.
• Includes results from multiple bioinformatics analyses (LASSO, GSEA, immune infiltration, regulatory networks).

Limitations

• The primary data file is an 11.0 KB PDF, suggesting the dataset is likely a summary or results document rather than raw or processed tabular data.
• Row count and column-level documentation are unknown, limiting suitability assessment for direct computational analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Juan He.

Collection Method

Bioinformatics analysis of transcriptome dataset GSE185011 using differential expression, enrichment, LASSO, and network analysis.

Freshness

Last updated 2026-04-28 05:24:44; freshness should be verified.