Imaging Mass Cytometry of the Immune Microenvironment in Alveolar Echinococcosis

Six patient liver tissue samples were analyzed using high-dimensional imaging mass cytometry to profile the immune landscape of alveolar echinococcosis. The data, authored by Yanyan Ma and last updated in May 2026, resolves sixteen immune cell types and their spatial distributions within lesion-proximal and lesion-distal regions. The study also compares neutrophil subset densities between pediatric and adult patients.

Use Cases

• Analyze spatial organization of immune cells based on the 16 resolved cell types and their described distributions.
• Investigate immune checkpoint expression patterns based on the described focal PD-1/PD-L1 co-expression and broad CD47 distribution.
• Compare myeloid–lymphoid crosstalk based on the described correlations between M2 macrophages, T cells, and neutrophils.
• Study age-related differences in immune response based on the higher neutrophil densities observed in pediatric patients.

Strengths

• Data includes samples from six patients with histologically confirmed alveolar echinococcosis.
• High-dimensional imaging mass cytometry enabled simultaneous profiling of immune infiltration, spatial heterogeneity, and checkpoint expression.
• The study provides the first spatially resolved map of the immune landscape in human AE.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 86.7 KB, indicating limited scope.

Provenance

Source

Yanyan Ma via figshare.

Collection Method

Imaging mass cytometry performed on liver tissue sections from six patients.

Freshness

Last updated 2026-05-08 05:56:02; freshness should be verified.