TP53 H179 Mutations in NSCLC: Structural Analysis from TCGA and Molecular Dynamics

TP53 gene mutations were present in 50% of lung adenocarcinoma and 81% of lung squamous cell carcinoma cases from The Cancer Genome Atlas. This research document details the structural and functional ramifications of specific His179 zinc-binding motif mutations in the p53 protein, analyzed via molecular dynamics simulations. The dataset, authored by Ankur Datta and last updated in April 2026, is a 822.2 KB document shared under a CC-BY-4.0 license.

Use Cases

• Study the prevalence of TP53 H179 mutations based on TCGA mutational profiles for 616 LUAD and 544 LUSC individuals.
• Analyze mutation-induced structural plasticity based on described conformational signatures and altered energy landscapes.
• Investigate zinc-binding affinity changes based on evaluated binding affinity values for H179 mutants.
• Examine residue-level interaction patterns based on contact maps comparing mutants to the wildtype protein.

Strengths

• Analysis is based on TCGA mutational profiles from a combined 1,160 LUAD and LUSC individuals.
• Focuses on a specific, underexplored structural locus (His179) within a critical cancer gene.
• Employs a multi-method approach combining static structural analysis and atomistic molecular dynamics simulations.

Limitations

• The dataset is a 822.2 KB DOCX file, suggesting limited scope and a focus on textual results rather than raw computational data.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, authored by Ankur Datta.

Collection Method

Analysis of TCGA mutational profiles combined with molecular dynamics simulations.

Time Range

Temporal coverage of the underlying TCGA data is not specified.

Freshness

Last updated 2026-04-10 05:59:21

Geography

Spatial coverage is not specified.