Plasma Exosomal Proteomics Data for Thyroid Disorders and Papillary Thyroid Carcinoma

Yawei Zhang's dataset contains proteomic data from plasma exosomes of patients with papillary thyroid carcinoma (PTC), PTC with Hashimoto’s thyroiditis (HT), HT alone, and healthy controls. The data includes results from label-free quantitative proteomics identifying 45 differentially expressed proteins, validated via parallel reaction monitoring. It was last updated on 2026-05-25.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on exosomal protein expression.
• Investigate immune response and extracellular matrix pathways implicated in thyroid cancer progression.
• Validate differential expression of specific proteins like SVEP1 and IGKV3-7 across patient cohorts.
• Develop non-invasive diagnostic models for thyroid disorders using plasma exosomal proteomic profiles.

Strengths

• Includes data from four distinct patient cohorts (PTC, PTC-W, HT, HCs) for comparative analysis.
• Validation phase confirmed statistically significant expression levels for SVEP1 and IGKV3-7.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is small (168.5 KB), indicating a limited scope of data.

Provenance

Source

Yawei Zhang via figshare

Collection Method

Exosome isolation and label-free quantitative proteomics from patient plasma samples.

Freshness

Last updated 2026-05-25 04:44:58; freshness should be verified.