Moringa Oleifera Peptic Ulcer Preclinical Meta-Analysis: 11 Studies

Presenting a systematic review and meta-analysis of 11 preclinical studies involving 268 animals, evaluating the therapeutic effect of Moringa oleifera extracts on peptic ulcer disease. It includes pooled analysis results such as standard mean difference (SMD = -1.42), confidence intervals, and subgroup analyses by dose and comparator.

Use Cases

• Analyze the relationship between Moringa oleifera dose and ulcer index reduction across 11 studies.
• Compare the standard mean difference (SMD) outcomes for high-dose Moringa versus standard drug controls.
• Examine heterogeneity (I²) and publication bias results from the meta-analysis methodology.
• Assess study quality using the reported SYRCLE scores ranging from 8 to 9.

Strengths

• Includes data from 11 eligible preclinical studies with a total of 268 animals.
• Reports specific meta-analysis metrics including SMD, 95% CI, p-values, and I² for heterogeneity.
• Uses a systematic review methodology with a registered protocol (CRD420251080346).

Limitations

• Limited to preclinical (rodent) studies, with no clinical trial data included.
• Small overall evidence base of 11 studies, limiting statistical power for some subgroup analyses.
• High heterogeneity (I² = 69%) reported in some comparisons, indicating methodological variability.

Provenance

Source

figshare, authored by Saheed Olatunbosun Akiode.

Collection Method

Systematic review and meta-analysis of studies from PubMed, CINAHL, Scopus, Web of Science, and Cochrane Library.

Time Range

Literature search from database inception to August 2025.

Freshness

Last updated March 20, 2026, with literature search up to August 2025.