Murine Sepsis Model Data on PD-L1 Role in Lung Injury and Mortality

Experimental data from a study using Cre-lox mouse models to investigate the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury and mortality. The dataset includes survival rates, lung vascular permeability measurements, and cytokine, chemokine, and angiopoietin levels from blood, bronchoalveolar lavage fluid, and lung tissue. It was authored by Elizabeth W. Tindal and last updated on June 2, 2026.

Use Cases

• Modeling the differential impact of endothelial vs. neutrophil PD-L1 on sepsis mortality based on survival data.
• Analyzing lung injury biomarkers based on cytokine, chemokine, and angiopoietin level measurements.
• Investigating lung vascular permeability changes based on Evan's Blue dye exclusion assay results.
• Comparing immune response profiles across different genetically modified mouse strains (ecPD-L1−/−, pmnPD-L1−/−, Controls).

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific PD-L1 knockout.
• Includes multiple biological measurements: survival, lung permeability, and cytokine/chemokine/angiopoietin levels.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Dataset size is 177.1 KB, indicating a very limited scope and likely small sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on murine models of hemorrhagic shock and cecal ligation and puncture (CLP).

Freshness

Last updated 2026-06-02 04:31:29; freshness should be verified.