Laron Mouse Liver RNA-seq Data from GH Receptor Gene Therapy Study

A figshare dataset by Joshua K. Tay, last updated in 2026, containing RNA sequencing results from a mouse model of Laron syndrome. The data compares liver gene expression across wild-type, GHR-deficient, and gene therapy-treated groups, identifying 448 significantly altered genes post-treatment. The dataset is small, at 153.3 KB, and is provided as a PDF file.

Use Cases

• Identify sex-biased gene expression patterns based on the enrichment analysis mentioned in the description.
• Analyze the effects of constitutive liver-specific promoters based on the reported upregulation of proto-oncogenes like Ascl1 and Tmprss4.
• Compare gene therapy efficacy to IGF-1 treatment based on the described limited increase in body metrics.
• Study the GH-responsive IGF signaling pathway based on the reported fold-changes in Igf1 and Igfals expression.

Strengths

• Includes data from four distinct experimental groups (wild-type, knockout, treatment, and vector control) for comparative analysis.
• Reports specific differential expression counts: 448 genes changed with therapy versus 2781 altered by GHR loss.
• Quantifies key gene expression changes, such as a ~16-fold induction of Igf1 and Igfals in the treatment group.
• Released under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• The core data is embedded in a 153.3 KB PDF, which likely contains summary results rather than raw or processed tabular data files.
• Column-level documentation is absent; field semantics must be inferred from the publication text.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

Joshua K. Tay via figshare.

Collection Method

RNA sequencing (RNA-seq) performed on mouse livers from genetically modified and treated groups.

Freshness

Last updated 2026-05-28 04:56:27; freshness should be verified.