Data Sheet 6_Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study.xlsx

Shuai Wang's 2026 figshare data sheet presents results from a transcriptomic and Mendelian randomization study on ankylosing spondylitis. The research identifies RORA, FBXO31, and MSRB3 as candidate biomarker genes with causal links to disease risk, validated by RT–qPCR. The dataset includes findings from functional enrichment, immune infiltration, and drug prediction analyses.

Use Cases

• Validate the causal association of ISR-related genes like RORA and FBXO31 with AS susceptibility using Mendelian randomization results.
• Analyze correlations between candidate biomarker expression levels and specific immune cell infiltration, such as Th1 cells and keratinocytes.
• Investigate predicted therapeutic agents, such as indirubin and pentoxifylline, linked to the identified biomarker genes.
• Explore functional enrichment results, including involvement in olfactory transduction pathways, for the differentially expressed genes.

Strengths

• Includes results from multiple analytical methods: transcriptomic profiling, Mendelian randomization, functional enrichment, and immune infiltration.
• Candidate biomarkers RORA, FBXO31, and MSRB3 were validated with RT–qPCR on clinically collected blood samples.
• Data is openly licensed under CC BY 4.0 for reuse.

Limitations

• Dataset is very small at 9.7 KB, indicating it contains summary results, not the underlying raw expression or genetic data.
• Sample size for the clinical validation and source of transcriptomic profiles are not specified, limiting reproducibility assessments.

Provenance

Source

Shuai Wang via figshare.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, Mendelian randomization analysis, followed by functional and drug prediction analyses and RT–qPCR validation.

Time Range

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Freshness

Last updated March 2026.

Geography

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